Synthesis and interactions of 7-deoxy-, 10-deacetoxy, and 10-deacetoxy-7-deoxypaclitaxel with NCI/ADR-RES cancer cells and bovine brain microvessel endothelial cells

Haibo Ge, Veena Vasandani, Jacquelyn K. Huff, Kenneth L. Audus, Richard H. Himes, Anna Seelig, Gunda I. Georg

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

7-Deoxypaclitaxel, 10-deacetoxypaclitaxel and 10-deacetoxy-7- deoxypaclitaxel were prepared and evaluated for their ability to promote assembly of tubulin into microtubules, their cytotoxicity against NCI/ADR-RES cells and for their interactions with P-glycoprotein in bovine brain microvessel endothelial cells. The three compounds were essentially equivalent to paclitaxel in cytotoxicity against NCI/ADR-RES cells. They also appeared to interact with P-glycoprotein in the endothelial cells with the two 10-deacetoxy compounds having less interaction than paclitaxel and 7-deoxypaclitaxel.

Original languageEnglish (US)
Pages (from-to)433-436
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume16
Issue number2
DOIs
StatePublished - Jan 15 2006

Fingerprint

Endothelial cells
P-Glycoprotein
Cytotoxicity
Paclitaxel
Microvessels
Brain
Endothelial Cells
Cells
Tubulin
Cell Communication
Microtubules
Neoplasms
10-deacetoxy-7-deoxypaclitaxel
7-deoxypaclitaxel
10-deacetoxypaclitaxel

Keywords

  • 10-Deacetoxy-7-deoxypaclitaxel
  • 10-Deacetoxypaclitaxel
  • 7-Deoxypaclitaxel
  • Bovine brain microvessel endothelial cells
  • NCI/ADR-RES
  • P-glycoprotein interaction
  • Synthesis

Cite this

Synthesis and interactions of 7-deoxy-, 10-deacetoxy, and 10-deacetoxy-7-deoxypaclitaxel with NCI/ADR-RES cancer cells and bovine brain microvessel endothelial cells. / Ge, Haibo; Vasandani, Veena; Huff, Jacquelyn K.; Audus, Kenneth L.; Himes, Richard H.; Seelig, Anna; Georg, Gunda I.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 16, No. 2, 15.01.2006, p. 433-436.

Research output: Contribution to journalArticle

Ge, Haibo ; Vasandani, Veena ; Huff, Jacquelyn K. ; Audus, Kenneth L. ; Himes, Richard H. ; Seelig, Anna ; Georg, Gunda I. / Synthesis and interactions of 7-deoxy-, 10-deacetoxy, and 10-deacetoxy-7-deoxypaclitaxel with NCI/ADR-RES cancer cells and bovine brain microvessel endothelial cells. In: Bioorganic and Medicinal Chemistry Letters. 2006 ; Vol. 16, No. 2. pp. 433-436.
@article{82042c27f7c14ca1855106ec05935dd1,
title = "Synthesis and interactions of 7-deoxy-, 10-deacetoxy, and 10-deacetoxy-7-deoxypaclitaxel with NCI/ADR-RES cancer cells and bovine brain microvessel endothelial cells",
abstract = "7-Deoxypaclitaxel, 10-deacetoxypaclitaxel and 10-deacetoxy-7- deoxypaclitaxel were prepared and evaluated for their ability to promote assembly of tubulin into microtubules, their cytotoxicity against NCI/ADR-RES cells and for their interactions with P-glycoprotein in bovine brain microvessel endothelial cells. The three compounds were essentially equivalent to paclitaxel in cytotoxicity against NCI/ADR-RES cells. They also appeared to interact with P-glycoprotein in the endothelial cells with the two 10-deacetoxy compounds having less interaction than paclitaxel and 7-deoxypaclitaxel.",
keywords = "10-Deacetoxy-7-deoxypaclitaxel, 10-Deacetoxypaclitaxel, 7-Deoxypaclitaxel, Bovine brain microvessel endothelial cells, NCI/ADR-RES, P-glycoprotein interaction, Synthesis",
author = "Haibo Ge and Veena Vasandani and Huff, {Jacquelyn K.} and Audus, {Kenneth L.} and Himes, {Richard H.} and Anna Seelig and Georg, {Gunda I.}",
year = "2006",
month = "1",
day = "15",
doi = "10.1016/j.bmcl.2005.09.043",
language = "English (US)",
volume = "16",
pages = "433--436",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier Limited",
number = "2",

}

TY - JOUR

T1 - Synthesis and interactions of 7-deoxy-, 10-deacetoxy, and 10-deacetoxy-7-deoxypaclitaxel with NCI/ADR-RES cancer cells and bovine brain microvessel endothelial cells

AU - Ge, Haibo

AU - Vasandani, Veena

AU - Huff, Jacquelyn K.

AU - Audus, Kenneth L.

AU - Himes, Richard H.

AU - Seelig, Anna

AU - Georg, Gunda I.

PY - 2006/1/15

Y1 - 2006/1/15

N2 - 7-Deoxypaclitaxel, 10-deacetoxypaclitaxel and 10-deacetoxy-7- deoxypaclitaxel were prepared and evaluated for their ability to promote assembly of tubulin into microtubules, their cytotoxicity against NCI/ADR-RES cells and for their interactions with P-glycoprotein in bovine brain microvessel endothelial cells. The three compounds were essentially equivalent to paclitaxel in cytotoxicity against NCI/ADR-RES cells. They also appeared to interact with P-glycoprotein in the endothelial cells with the two 10-deacetoxy compounds having less interaction than paclitaxel and 7-deoxypaclitaxel.

AB - 7-Deoxypaclitaxel, 10-deacetoxypaclitaxel and 10-deacetoxy-7- deoxypaclitaxel were prepared and evaluated for their ability to promote assembly of tubulin into microtubules, their cytotoxicity against NCI/ADR-RES cells and for their interactions with P-glycoprotein in bovine brain microvessel endothelial cells. The three compounds were essentially equivalent to paclitaxel in cytotoxicity against NCI/ADR-RES cells. They also appeared to interact with P-glycoprotein in the endothelial cells with the two 10-deacetoxy compounds having less interaction than paclitaxel and 7-deoxypaclitaxel.

KW - 10-Deacetoxy-7-deoxypaclitaxel

KW - 10-Deacetoxypaclitaxel

KW - 7-Deoxypaclitaxel

KW - Bovine brain microvessel endothelial cells

KW - NCI/ADR-RES

KW - P-glycoprotein interaction

KW - Synthesis

UR - http://www.scopus.com/inward/record.url?scp=27944455124&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=27944455124&partnerID=8YFLogxK

U2 - 10.1016/j.bmcl.2005.09.043

DO - 10.1016/j.bmcl.2005.09.043

M3 - Article

VL - 16

SP - 433

EP - 436

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

SN - 0960-894X

IS - 2

ER -