Synthesis and evaluation of novel carbazole derivatives as free radical scavengers

N. Naik, H. Vijay Kumar, H. Swetha

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8 Scopus citations


A series of carbazole conjugated with different aminophenols and substituted aminophenols were synthesized by base catalyzed condensation reaction. The key intermediate 1-(9H-carbazol-9-yl)-2-chloroethanone, was obtained by Nacylation of carbazole with chloroacetyl chloride. The newly synthesized compounds were characterized by spectral and elemental analysis data and studied for their radical scavenging activity using 2, 2-diphenyl-1- picrylhydrazyl (DPPH) assay. Butylated hydroxy anisole (BHA) was used as a reference antioxidant compound and the comparative study with newly synthesized compounds was also done. Among the analogues, 1-(9H-carbazole-9-yl)-2-(4- hydroxy-3-rnethoxyphenylamino)ethanone, bearing electron donating methoxy substituent in the phenolic moiety, showed predominant activity.

Original languageEnglish (US)
Pages (from-to)40-45
Number of pages6
JournalBulgarian Chemical Communications
Issue number1
StatePublished - Jul 2 2010


  • 1-(9H-carbazol-9-yl)-2-chloroethanone and radical scavenging activity
  • Carbazole


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