Synthesis and evaluation of a β-lactam-containing dipeptide analog as a protease inhibitor

Zhijun Wu, Gunda I. Georg, Brian E. Cathers, John V. Schloss

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

A monocyclic 3-amino-β-lactam analog of the dipeptide Phe-Gly methyl ester has been synthesized as a potential protease inhibitor. This β-lactam is a non-time-dependent inhibitor of α-chymotrypsin, carboxypeptidase Y, and cathepsin G.

Original languageEnglish (US)
Pages (from-to)983-986
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume6
Issue number8
DOIs
StatePublished - Apr 23 1996

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