Synthesis and Evaluation of 4-(Substituted thio)-4-androstene-3,17-dione Derivatives as Potential Aromatase Inhibitors

Keyphrases

• Aromatase Inhibitors 100%
• Thio 100%
• 4-androstene-3,17-dione (4-AD) 100%
• Inhibitory Activity 66%
• Synthesized Compounds 66%
• Estrogen 33%
• Synthetase 33%
• Competitive Inhibitor 33%
• Androstenedione 33%
• Aromatase 33%
• Initial Velocity 33%
• Thiol Reagents 33%
• Microsomal Preparation 33%
• Enzyme Sources 33%

Chemistry

• Inhibition Constant (Ki) 100%
• Aromatase Inhibitor 100%
• Androstenedione 50%
• Aromatase 50%
• Km 50%
• Volume 50%
• Thiol 50%

Pharmacology, Toxicology and Pharmaceutical Science

• Aromatase Inhibitor 100%
• Androstenedione 100%
• Aromatase 50%
• Competitive Inhibitor 25%
• Thiol Reagent 25%