Synthesis and dopamine receptor modulating activity of substituted bicyclic thiazolidine lactam peptidomimetics of L-prolyl-L-leucyl-glycinamide

Ehab M. Khalil, Ashish Pradhan, William H. Ojala, William B. Gleason, Ram K. Mishra, Rodney L. Johnson

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

6-Substituted bicyclic thiazolidine lactam peptidomimetics of Pro-Leu- Gly-NH2 (1) were synthesized to test the hypothesis that incorporation of a hydrophobic side chain into the bicyclic thiazolidine lactam scaffold would further enhance the dopamine receptor modulating activity of such peptidomimetics. The substituents employed were the isobutyl, butyl, and benzyl groups to give peptidomimetics 3-5, respectively. These peptidomimetics were evaluated in vivo as modulators of apomorphine-induced rotational behavior in the 6-hydroxydopamine-lesioned rat model of hemiparkinsonism and were compared with the unsubstituted bicyclic thiazolidine lactam Pro-Leu-Gly-NH2 peptidomimetic 2. Peptidomimetics 3-5 each affected rotational behavior in a bell-shaped dose-response relationship producing maximal increases of 44% (1 μg/kg, ip), 56% (0.1μg/kg, ip), and 30% (1μg/kg, ip), respectively. In comparison, unsubstituted peptidomimetic 2 increased rotational behavior by only 23% at a dose of 0.1 μg/kg, ip.

Original languageEnglish (US)
Pages (from-to)2977-2987
Number of pages11
JournalJournal of medicinal chemistry
Volume42
Issue number15
DOIs
StatePublished - Jul 29 1999

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