Synthesis and DNA binding affinity of novel A-C8/C-C2-exo unsaturated alkoxyamido-linked pyrrolo[2,1-c][1,4]benzodiazepine dimers

Ahmed Kamal; O. Srinivas; P. Ramulu; G. Ramesh; P. Praveen Kumar; M. Shiva Kumar

doi:10.1016/j.bmc.2004.06.013

Synthesis and DNA binding affinity of novel A-C8/C-C2-exo unsaturated alkoxyamido-linked pyrrolo[2,1-c][1,4]benzodiazepine dimers

Ahmed Kamal
, O. Srinivas
, P. Ramulu
, G. Ramesh
, P. Praveen Kumar
, M. Shiva Kumar

Center for Drug Design

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

The synthesis of novel A-C8/C-C2-exo unsaturated alkoxyamido-linked pyrrolo[2,1-c][1,4]benzodiazepine dimers is reported and these dimers show significant DNA binding affinity and they also exhibit moderate anticancer activity.

Original language	English (US)
Pages (from-to)	4337-4350
Number of pages	14
Journal	Bioorganic and Medicinal Chemistry
Volume	12
Issue number	16
DOIs	https://doi.org/10.1016/j.bmc.2004.06.013
State	Published - Aug 15 2004

Bibliographical note

Funding Information:
We thank the National Cancer Institute, Maryland for the in vitro anticancer assay in human cancer cell lines. We are also grateful to CSIR, New Delhi for the award of research fellowships to O.S., P.R., G.R. and P.P.K.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cytotoxicity
DNA binding affinity
Pyrrolobenzodiazepine dimers

Publisher link

10.1016/j.bmc.2004.06.013

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title = "Synthesis and DNA binding affinity of novel A-C8/C-C2-exo unsaturated alkoxyamido-linked pyrrolo[2,1-c][1,4]benzodiazepine dimers",

abstract = "The synthesis of novel A-C8/C-C2-exo unsaturated alkoxyamido-linked pyrrolo[2,1-c][1,4]benzodiazepine dimers is reported and these dimers show significant DNA binding affinity and they also exhibit moderate anticancer activity.",

keywords = "Cytotoxicity, DNA binding affinity, Pyrrolobenzodiazepine dimers",

author = "Ahmed Kamal and O. Srinivas and P. Ramulu and G. Ramesh and Kumar, \{P. Praveen\} and Kumar, \{M. Shiva\}",

note = "Funding Information: We thank the National Cancer Institute, Maryland for the in vitro anticancer assay in human cancer cell lines. We are also grateful to CSIR, New Delhi for the award of research fellowships to O.S., P.R., G.R. and P.P.K.",

year = "2004",

month = aug,

day = "15",

doi = "10.1016/j.bmc.2004.06.013",

language = "English (US)",

volume = "12",

pages = "4337--4350",

journal = "Bioorganic and Medicinal Chemistry",

issn = "0968-0896",

publisher = "Elsevier Ltd",

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TY - JOUR

T1 - Synthesis and DNA binding affinity of novel A-C8/C-C2-exo unsaturated alkoxyamido-linked pyrrolo[2,1-c][1,4]benzodiazepine dimers

AU - Kamal, Ahmed

AU - Srinivas, O.

AU - Ramulu, P.

AU - Ramesh, G.

AU - Kumar, P. Praveen

AU - Kumar, M. Shiva

N1 - Funding Information: We thank the National Cancer Institute, Maryland for the in vitro anticancer assay in human cancer cell lines. We are also grateful to CSIR, New Delhi for the award of research fellowships to O.S., P.R., G.R. and P.P.K.

PY - 2004/8/15

Y1 - 2004/8/15

N2 - The synthesis of novel A-C8/C-C2-exo unsaturated alkoxyamido-linked pyrrolo[2,1-c][1,4]benzodiazepine dimers is reported and these dimers show significant DNA binding affinity and they also exhibit moderate anticancer activity.

AB - The synthesis of novel A-C8/C-C2-exo unsaturated alkoxyamido-linked pyrrolo[2,1-c][1,4]benzodiazepine dimers is reported and these dimers show significant DNA binding affinity and they also exhibit moderate anticancer activity.

KW - Cytotoxicity

KW - DNA binding affinity

KW - Pyrrolobenzodiazepine dimers

UR - https://www.scopus.com/pages/publications/3242809006

UR - https://www.scopus.com/pages/publications/3242809006#tab=citedBy

U2 - 10.1016/j.bmc.2004.06.013

DO - 10.1016/j.bmc.2004.06.013

M3 - Article

C2 - 15265486

AN - SCOPUS:3242809006

SN - 0968-0896

VL - 12

SP - 4337

EP - 4350

JO - Bioorganic and Medicinal Chemistry

JF - Bioorganic and Medicinal Chemistry

IS - 16

ER -

Synthesis and DNA binding affinity of novel A-C8/C-C2-exo unsaturated alkoxyamido-linked pyrrolo[2,1-c][1,4]benzodiazepine dimers

Abstract

Bibliographical note

UN SDGs

Keywords

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