Synthesis and characterization of biocompatible and size-tunable multifunctional porous silica nanoparticles

Yu Shen Lin, Christy L. Haynes

Research output: Contribution to journalArticlepeer-review

335 Scopus citations


In this work, size-controlled multifunctional mesoporous silica nanoparticles having large surface areas, embedded luminescence, high magnetization, and excellent aqueous dispersity have been successfully prepared by using a simple one-pot synthesis. The size and pore ordering of these particles can be easily controlled based on the number density of Fe 3O 4 nanoparticle nucleation sites introduced during the silica condensation reaction. Dissolution of the embedded Fe 3O 4 nanoparticles yields hollow mesoporous silica nanoparticles as well. These multifunctional porous nanoparticles were characterized by transmission electron microscopy, X-ray diffraction, nitrogen adsorption-desorption behavior, dynamic light scattering, zeta potential, magnetic susceptibility, and photoluminescence. Furthermore, in vitro 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (MTT) and hemolysis assays were performed to evaluate any unintended cytotoxicity. The biocompatibility of the multifunctional nanoparticles, even at very high doses, ensures their potential in biomedical applications.

Original languageEnglish (US)
Pages (from-to)3979-3986
Number of pages8
JournalChemistry of Materials
Issue number17
StatePublished - Sep 8 2009


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