Synthesis and biology of substituted 3′-phenyl taxol analogues

Gunda I. Georg, Zacharia S. Cheruvallath, Geraldin C.B. Harriman, Michael Hepperle, Haeil Park, Richard H. Himes

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

A series of substituted 3′-phenyl taxol analogues, directed by the Topliss Operational Scheme, were synthesized and evaluated for their biological activity. The novel analogues were prepared from baccatin III and N-acyl β-lactams. Evaluation in the microtubule assembly assay and for cytotoxicity against B16 melanoma cells illustrated a modest influence of aromatic substitution on bioactivity.

Original languageEnglish (US)
Pages (from-to)2331-2336
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume4
Issue number19
DOIs
StatePublished - Oct 6 1994

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