Synthesis and biological evaluation of carboacyclic nucleosides with (Z) and (E)-9-[4,4-bis(hydroxymethyl)]-2-butenyl side chain

Ye Tang; Ramaiah Muthyala; Robert Vince

doi:10.1016/j.bmc.2006.05.029

Synthesis and biological evaluation of carboacyclic nucleosides with (Z) and (E)-9-[4,4-bis(hydroxymethyl)]-2-butenyl side chain

Ye Tang
, Ramaiah Muthyala
, Robert Vince

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

A series of carboacyclic nucleosides with (Z) and (E)-9-[4,4-bis(hydroxy-methyl)]-2-butenyl side chains were synthesized as ring open analogs of cyclohexene nucleosides 1 and bioisosteres of ganciclovir 3. The (E)-isomers were obtained to compare the side chain geometry effect on antiviral activity.

Original language	English (US)
Pages (from-to)	5866-5875
Number of pages	10
Journal	Bioorganic and Medicinal Chemistry
Volume	14
Issue number	17
DOIs	https://doi.org/10.1016/j.bmc.2006.05.029
State	Published - Sep 1 2006

Keywords

Antiviral
Bioisosteres
Carboacyclic
Nucleosides

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10.1016/j.bmc.2006.05.029

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abstract = "A series of carboacyclic nucleosides with (Z) and (E)-9-[4,4-bis(hydroxy-methyl)]-2-butenyl side chains were synthesized as ring open analogs of cyclohexene nucleosides 1 and bioisosteres of ganciclovir 3. The (E)-isomers were obtained to compare the side chain geometry effect on antiviral activity.",

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AU - Muthyala, Ramaiah

AU - Vince, Robert

PY - 2006/9/1

Y1 - 2006/9/1

N2 - A series of carboacyclic nucleosides with (Z) and (E)-9-[4,4-bis(hydroxy-methyl)]-2-butenyl side chains were synthesized as ring open analogs of cyclohexene nucleosides 1 and bioisosteres of ganciclovir 3. The (E)-isomers were obtained to compare the side chain geometry effect on antiviral activity.

AB - A series of carboacyclic nucleosides with (Z) and (E)-9-[4,4-bis(hydroxy-methyl)]-2-butenyl side chains were synthesized as ring open analogs of cyclohexene nucleosides 1 and bioisosteres of ganciclovir 3. The (E)-isomers were obtained to compare the side chain geometry effect on antiviral activity.

KW - Antiviral

KW - Bioisosteres

KW - Carboacyclic

KW - Nucleosides

UR - https://www.scopus.com/pages/publications/33746260250

UR - https://www.scopus.com/pages/publications/33746260250#tab=citedBy

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SN - 0968-0896

VL - 14

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EP - 5875

JO - Bioorganic and Medicinal Chemistry

JF - Bioorganic and Medicinal Chemistry

IS - 17

ER -

Synthesis and biological evaluation of carboacyclic nucleosides with (Z) and (E)-9-[4,4-bis(hydroxymethyl)]-2-butenyl side chain

Abstract

Keywords

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