A series of carboacyclic nucleosides with (Z) and (E)-9-[4,4-bis(hydroxy-methyl)]-2-butenyl side chains were synthesized as ring open analogs of cyclohexene nucleosides 1 and bioisosteres of ganciclovir 3. The (E)-isomers were obtained to compare the side chain geometry effect on antiviral activity.
|Original language||English (US)|
|Number of pages||10|
|Journal||Bioorganic and Medicinal Chemistry|
|State||Published - Sep 1 2006|