Synthesis and biological evaluation of a biotinylated paclitaxel with an extra-long chain spacer arm

Lev G. Lis, Mary A. Smart, Anna Luchniak, Mohan L. Gupta, Vadim J. Gurvich

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

A biotinylated paclitaxel derivative with an extra-long chain (LC-LC-biotin) spacer arm was synthesized using an improved synthetic reaction sequence. The biotinylated paclitaxel analogue retained excellent microtubule stabilizing activity in vitro. Furthermore, it was shown that this analogue can simultaneously engage streptavidin and the binding site on microtubules, making it suitable for localization studies or for the attachment of paclitaxel to solid substrates via a streptavidin linkage.

Original languageEnglish (US)
Pages (from-to)745-748
Number of pages4
JournalACS Medicinal Chemistry Letters
Volume3
Issue number9
DOIs
StatePublished - Sep 13 2012

Keywords

  • biotin
  • biotinylated
  • paclitaxel
  • taxol

Fingerprint

Dive into the research topics of 'Synthesis and biological evaluation of a biotinylated paclitaxel with an extra-long chain spacer arm'. Together they form a unique fingerprint.

Cite this