Synthesis and biological evaluation of 2,3‐diazabicyclo[2.2.1]heptane derivatives as prostaglandin endoperoxide analogs

Sheung‐Tsam ‐T Kam, Robert N. Hanson, Philip S. Portoghese

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Abstract

Three prostaglandin endoperoxide analogs that possess the 2,3‐diazabicyclo[2.2.1]heptane skeleton were synthesized and evaluated for activity in human platelets and in the rat fundus. All three compounds were inactive in inhibiting or stimulating platelet aggregation. One compound possessed weak contracting activity on the rat fundus.

Original languageEnglish (US)
Pages (from-to)1007-1010
Number of pages4
JournalJournal of Pharmaceutical Sciences
Volume69
Issue number9
DOIs
StatePublished - Sep 1980

Keywords

  • Platelet aggregation—evaluation of inhibition and stimulation by prostaglandin endoperoxide analogs
  • Prostaglandin endoperoxide analogs—synthesis and evaluation for inhibition and stimulation of platelet aggregation

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