Synthesis and biological activity of O-glycosylated morphiceptin analogues

Eduard Bardají, Joseph L. Torres, Pere Clapés, Fernando Albericio, George Barany, Raquel E. Rodríguez, María P. Sacristán, Gregorio Valencia

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

The synthesis and biological activity of [Hyp4]morphiceptin and two glycosyl derivatives are reported. Glycopeptide amides were obtained using Fmoc solid-phase chemistry and mild conditions for cleavage from a tris(alkoxy)benzylamide (PAL) resin. Analogues were evaluated in the guinea pig ileum in vitro assay and in in vivo tail-flick and paw-pressure antinociceptive tests after intrathecal administration in rats. Substitution of Pro4 by Hyp4, and further derivatization of Hyp with glucose or galactose, resulted in an unexpected decrease in biological activity with respect to morphiceptin.

Original languageEnglish (US)
Pages (from-to)1755-1759
Number of pages5
JournalJournal of the Chemical Society, Perkin Transactions 1
Issue number7
DOIs
StatePublished - 1991

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