Synthesis and antibacterial activity of 6-aryl-3-(2′-methyl-1′, 8′-naphthyridin-3′-yl)-1, 2, 4-triazolo-[3,4-b][1,3,4]thiadiazoles

H. Shailaja Rani, K. Mogilaiah, J. Sudhakar Rao, B. Sreenivasulu

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

2-Methyl-1, 8-naphthyridine-3-carboxylic acid hydrazide 2 on reaction with CS2 in the presence of KOH affords 5-mercapto-2-(2′-methyl-1′, 8′-naphthyridin-3′-yl)-1, 3, 4-oxadiazole 3, which is converted into 4-amino-5-mercapto-3-(2′-methyl-1′, 8′-naphthyridin-3′-yl)-1, 2, 4-triazole 4 by the reaction with hydrazine hydrate. Cyclization of 4 with aromatic acids in refluxing POCl3 yields 6-aryl-3-(2′-methyl-1′, 8′-naphthyridin-3′-yl)-1, 2, 4-triazolo[3, 4-b][1, 3, 4]thiadiazoles 5. Compounds 5 have been tested for their antibacterial activity.

Original languageEnglish (US)
Pages (from-to)745-747
Number of pages3
JournalIndian Journal of Chemistry - Section B Organic and Medicinal Chemistry
Volume35
Issue number7
StatePublished - Jul 1 1996
Externally publishedYes

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