Synthesis (and alternative proof of configuration) of the scyphostatin C(1′)-C(20′) trienoyl fragment

Thomas R. Hoye, Manomi A. Tennakoon

Research output: Contribution to journalArticlepeer-review

58 Scopus citations

Abstract

(Matrix Presented) Each of four diastereomers of structure 2, corresponding to the lipophilic side chain of scyphostatin (1), were prepared. Careful analysis of their NMR spectral data and comparison with those of the natural product corroborates the recently reported (Org. Lett. 2000, 2, 505) stereochemical assignment. A strategy for the stereoselective synthesis of 2 has been achieved.

Original languageEnglish (US)
Pages (from-to)1481-1483
Number of pages3
JournalOrganic Letters
Volume2
Issue number10
DOIs
StatePublished - May 18 2000

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