Synthesis and activity of new acylated diaminohydroxyalkanes as human immunodeficiency virus protease inhibitors

Mauro Marastoni; Martina Bazzaro; Fabrizio Bortolotti; Roberto Tomatis

doi:10.1055/s-0031-1300250

Synthesis and activity of new acylated diaminohydroxyalkanes as human immunodeficiency virus protease inhibitors

Mauro Marastoni
, Martina Bazzaro
, Fabrizio Bortolotti
, Roberto Tomatis

Obstetrics, Gynecology and Women's Health - Gynecologic Oncology

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

A series of HIV-1 protease inhibitors based on the lead compound Pc (IC₅₀ = 165 nmol/l) with structural modifications at P1/P1' substituents or with a lengthening at its core unit were synthesized from amino acid starting materials. All analogues were less active than Pc against the protease.

Original language	English (US)
Pages (from-to)	564-568
Number of pages	5
Journal	Arzneimittel-Forschung/Drug Research
Volume	50
Issue number	6
DOIs	https://doi.org/10.1055/s-0031-1300250
State	Published - 2000

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

HIV-1 protease inhibitors
Peptidomimetics

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10.1055/s-0031-1300250

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abstract = "A series of HIV-1 protease inhibitors based on the lead compound Pc (IC50 = 165 nmol/l) with structural modifications at P1/P1' substituents or with a lengthening at its core unit were synthesized from amino acid starting materials. All analogues were less active than Pc against the protease.",

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AU - Marastoni, Mauro

AU - Bazzaro, Martina

AU - Bortolotti, Fabrizio

AU - Tomatis, Roberto

PY - 2000

Y1 - 2000

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AB - A series of HIV-1 protease inhibitors based on the lead compound Pc (IC50 = 165 nmol/l) with structural modifications at P1/P1' substituents or with a lengthening at its core unit were synthesized from amino acid starting materials. All analogues were less active than Pc against the protease.

KW - HIV-1 protease inhibitors

KW - Peptidomimetics

UR - https://www.scopus.com/pages/publications/0033946219

UR - https://www.scopus.com/pages/publications/0033946219#tab=citedBy

U2 - 10.1055/s-0031-1300250

DO - 10.1055/s-0031-1300250

M3 - Article

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AN - SCOPUS:0033946219

SN - 0004-4172

VL - 50

SP - 564

EP - 568

JO - Arzneimittel-Forschung/Drug Research

JF - Arzneimittel-Forschung/Drug Research

IS - 6

ER -

Synthesis and activity of new acylated diaminohydroxyalkanes as human immunodeficiency virus protease inhibitors

Abstract

UN SDGs

Keywords

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