Abstract
A series of HIV-1 protease inhibitors based on the lead compound Pc (IC50 = 165 nmol/l) with structural modifications at P1/P1' substituents or with a lengthening at its core unit were synthesized from amino acid starting materials. All analogues were less active than Pc against the protease.
Original language | English (US) |
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Pages (from-to) | 564-568 |
Number of pages | 5 |
Journal | Arzneimittel-Forschung/Drug Research |
Volume | 50 |
Issue number | 6 |
DOIs | |
State | Published - 2000 |
Keywords
- HIV-1 protease inhibitors
- Peptidomimetics