Synthesis and activity of new acylated diaminohydroxyalkanes as human immunodeficiency virus protease inhibitors

Mauro Marastoni; Martina Bazzaro; Fabrizio Bortolotti; Roberto Tomatis

doi:10.1055/s-0031-1300250

Synthesis and activity of new acylated diaminohydroxyalkanes as human immunodeficiency virus protease inhibitors

Mauro Marastoni, Martina Bazzaro, Fabrizio Bortolotti, Roberto Tomatis

Obstetrics, Gynecology and Women's Health - Oncology

Research output: Contribution to journal › Article › peer-review

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Abstract

A series of HIV-1 protease inhibitors based on the lead compound Pc (IC₅₀ = 165 nmol/l) with structural modifications at P1/P1' substituents or with a lengthening at its core unit were synthesized from amino acid starting materials. All analogues were less active than Pc against the protease.

Original language	English (US)
Pages (from-to)	564-568
Number of pages	5
Journal	Arzneimittel-Forschung/Drug Research
Volume	50
Issue number	6
DOIs	https://doi.org/10.1055/s-0031-1300250
State	Published - 2000

Keywords

HIV-1 protease inhibitors
Peptidomimetics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1055/s-0031-1300250

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abstract = "A series of HIV-1 protease inhibitors based on the lead compound Pc (IC50 = 165 nmol/l) with structural modifications at P1/P1' substituents or with a lengthening at its core unit were synthesized from amino acid starting materials. All analogues were less active than Pc against the protease.",

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AU - Tomatis, Roberto

PY - 2000

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AB - A series of HIV-1 protease inhibitors based on the lead compound Pc (IC50 = 165 nmol/l) with structural modifications at P1/P1' substituents or with a lengthening at its core unit were synthesized from amino acid starting materials. All analogues were less active than Pc against the protease.

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KW - Peptidomimetics

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Synthesis and activity of new acylated diaminohydroxyalkanes as human immunodeficiency virus protease inhibitors

Abstract

Keywords

UN SDGs

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