A series of HIV-1 protease inhibitors based on the lead compound Pc (IC50 = 165 nmol/l) with structural modifications at P1/P1' substituents or with a lengthening at its core unit were synthesized from amino acid starting materials. All analogues were less active than Pc against the protease.
|Original language||English (US)|
|Number of pages||5|
|State||Published - 2000|
- HIV-1 protease inhibitors