Syntheses of human TLR8-specific small-molecule agonists

Mallesh Beesu; Hari Prasad Kokatla; Sunil A. David

doi:10.1007/978-1-4939-6445-1_3

Syntheses of human TLR8-specific small-molecule agonists

Mallesh Beesu, Hari Prasad Kokatla, Sunil A. David

Medicinal Chemistry

Research output: Chapter in Book/Report/Conference proceeding › Chapter

4 Scopus citations

Abstract

Human toll-like receptor (hTLR)-8 is expressed in myeloid dendritic cells, monocytes, and monocytederived dendritic cells. Engagement by TLR8 agonists evokes a distinct cytokine profile which favors the development of type 1 helper T cells. Focused exploration of structure-activity relationships in the imidazoquinolines has led to the identification of several novel human TLR8-specific agonists. The synthetic procedures for best-in-class analogues encompassing four chemotypes are described.

Original language	English (US)
Title of host publication	Methods in Molecular Biology
Publisher	Humana Press Inc.
Pages	29-44
Number of pages	16
DOIs	https://doi.org/10.1007/978-1-4939-6445-1_3
State	Published - 2017

Publication series

Name	Methods in Molecular Biology
Volume	1494
ISSN (Print)	1064-3745

Bibliographical note

Funding Information:
This work was supported by NIH/NIAID contracts HSN272200900033C and HHSN272201400056C.

Publisher Copyright:
© Springer Science+Business Media New York 2017.

Keywords

Innate immunity
TLR8
TLR8 agonists
Vaccine adjuvants

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10.1007/978-1-4939-6445-1_3

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abstract = "Human toll-like receptor (hTLR)-8 is expressed in myeloid dendritic cells, monocytes, and monocytederived dendritic cells. Engagement by TLR8 agonists evokes a distinct cytokine profile which favors the development of type 1 helper T cells. Focused exploration of structure-activity relationships in the imidazoquinolines has led to the identification of several novel human TLR8-specific agonists. The synthetic procedures for best-in-class analogues encompassing four chemotypes are described.",

keywords = "Innate immunity, TLR8, TLR8 agonists, Vaccine adjuvants",

author = "Mallesh Beesu and Kokatla, {Hari Prasad} and David, {Sunil A.}",

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AU - Beesu, Mallesh

AU - Kokatla, Hari Prasad

AU - David, Sunil A.

N1 - Funding Information: This work was supported by NIH/NIAID contracts HSN272200900033C and HHSN272201400056C. Publisher Copyright: © Springer Science+Business Media New York 2017.

PY - 2017

Y1 - 2017

N2 - Human toll-like receptor (hTLR)-8 is expressed in myeloid dendritic cells, monocytes, and monocytederived dendritic cells. Engagement by TLR8 agonists evokes a distinct cytokine profile which favors the development of type 1 helper T cells. Focused exploration of structure-activity relationships in the imidazoquinolines has led to the identification of several novel human TLR8-specific agonists. The synthetic procedures for best-in-class analogues encompassing four chemotypes are described.

AB - Human toll-like receptor (hTLR)-8 is expressed in myeloid dendritic cells, monocytes, and monocytederived dendritic cells. Engagement by TLR8 agonists evokes a distinct cytokine profile which favors the development of type 1 helper T cells. Focused exploration of structure-activity relationships in the imidazoquinolines has led to the identification of several novel human TLR8-specific agonists. The synthetic procedures for best-in-class analogues encompassing four chemotypes are described.

KW - Innate immunity

KW - TLR8

KW - TLR8 agonists

KW - Vaccine adjuvants

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AN - SCOPUS:84991213592

T3 - Methods in Molecular Biology

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BT - Methods in Molecular Biology

PB - Humana Press Inc.

ER -

Syntheses of human TLR8-specific small-molecule agonists

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