@inbook{389e82ed0c0548c49c8f330e07fd1e2d,
title = "Syntheses of human TLR8-specific small-molecule agonists",
abstract = "Human toll-like receptor (hTLR)-8 is expressed in myeloid dendritic cells, monocytes, and monocytederived dendritic cells. Engagement by TLR8 agonists evokes a distinct cytokine profile which favors the development of type 1 helper T cells. Focused exploration of structure-activity relationships in the imidazoquinolines has led to the identification of several novel human TLR8-specific agonists. The synthetic procedures for best-in-class analogues encompassing four chemotypes are described.",
keywords = "Innate immunity, TLR8, TLR8 agonists, Vaccine adjuvants",
author = "Mallesh Beesu and Kokatla, {Hari Prasad} and David, {Sunil A.}",
year = "2017",
month = jan,
day = "1",
doi = "10.1007/978-1-4939-6445-1_3",
language = "English (US)",
series = "Methods in Molecular Biology",
publisher = "Humana Press Inc.",
pages = "29--44",
booktitle = "Methods in Molecular Biology",
}