Syntaxin is required for cell division

Sean D. Conner, Gary M. Wessel

Research output: Contribution to journalArticle

52 Scopus citations

Abstract

We recently identified a single family member homologue of syntaxin in the sea urchin. Syntaxin is present throughout development, and in rapidly dividing cleavage stage embryos it is present on numerous vesicles at the cell cortex. We hypothesized that syntaxin mediates essential membrane fusion events during early embryogenesis, reasoning that the vesicles and/or their contents are important for development. Here we show that functional inactivation of syntaxin with either Botulinum neurotoxin C1, which specifically proteolyzes syntaxin, or antibodies against syntaxin results in an inhibition of cell division. These observations suggest that syntaxin is essential for membrane fusion events critical for cell division.

Original languageEnglish (US)
Pages (from-to)2735-2743
Number of pages9
JournalMolecular biology of the cell
Volume10
Issue number8
DOIs
StatePublished - Aug 1999

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