Synopsis of partial-body radiation diagnostic biomarkers and medical management of radiation injury workshop

Pataje G.S. Prasanna, William F. Blakely, Jean Marc Bertho, John P. Chute, Eric P. Cohen, Ronald E. Goans, Marcy B. Grace, Patricia K. Lillis-Hearne, David C. Lloyd, Ludy C.H.W. Lutgens, Viktor Meineke, Natalia I. Ossetrova, Alexander Romanyukha, Julie D. Saba, Daniel J. Weisdorf, Andrzej Wojcik, Eduardo G. Yukihara, Terry C. Pellmar

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

Radiation exposures from accidents, nuclear detonations or terrorist incidents are unlikely to be homogeneous; however, current biodosimetric approaches are developed and validated primarily in whole-body irradiation models. A workshop was held at the Armed Forces Radiobiology Research Institute in May 2008 to draw attention to the need for partial-body biodosimetry, to discuss current knowledge, and to identify the gaps to be filled. A panel of international experts and the workshop attendees discussed the requirements and concepts for a path forward. This report addresses eight key areas identified by the Workshop Program Committee for future focus: (1) improved cytogenetics, (2) clinical signs and symptoms, (3) cutaneous bioindicators, (4) organ-specific biomarkers, (5) biophysical markers of dose, (6) integrated diagnostic approaches, (7) confounding factors, and (8) requirements for post-event medical follow-up. For each area, the status, advantages and limitations of existing approaches and suggestions for new directions are presented.

Original languageEnglish (US)
Pages (from-to)245-253
Number of pages9
JournalRadiation research
Volume173
Issue number2
DOIs
StatePublished - Feb 2010

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