TY - JOUR
T1 - Synergy within structural biology of single crystal optical spectroscopy and X-ray crystallography
AU - De la Mora-Rey, Teresa
AU - Wilmot, Carrie M.
N1 - Funding Information:
TMR would like to thank Bryan Johnson for helpful discussions. We acknowledge financial support from the National Institutes of Health (GM-66569).
PY - 2007/10
Y1 - 2007/10
N2 - Advances in the adaptation of optical spectroscopy to monitor photo-induced or enzyme-catalyzed reactions in the crystalline state have enabled X-ray crystal structures to be accurately linked with spectroscopically defined intermediates. This, in turn, has led to a deeper understanding of the role protein structural changes play in function. The integration of optical spectroscopy with X-ray crystallography is growing and now extends beyond linking crystal structure to reaction intermediate. Recent examples of this synergy include applications in protein crystallization, X-ray data acquisition, radiation damage, and acquisition of phase information important for structure determination.
AB - Advances in the adaptation of optical spectroscopy to monitor photo-induced or enzyme-catalyzed reactions in the crystalline state have enabled X-ray crystal structures to be accurately linked with spectroscopically defined intermediates. This, in turn, has led to a deeper understanding of the role protein structural changes play in function. The integration of optical spectroscopy with X-ray crystallography is growing and now extends beyond linking crystal structure to reaction intermediate. Recent examples of this synergy include applications in protein crystallization, X-ray data acquisition, radiation damage, and acquisition of phase information important for structure determination.
UR - http://www.scopus.com/inward/record.url?scp=35648929906&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=35648929906&partnerID=8YFLogxK
U2 - 10.1016/j.sbi.2007.09.005
DO - 10.1016/j.sbi.2007.09.005
M3 - Review article
C2 - 17959373
AN - SCOPUS:35648929906
SN - 0959-440X
VL - 17
SP - 580
EP - 586
JO - Current Opinion in Structural Biology
JF - Current Opinion in Structural Biology
IS - 5
ER -