Synergistic effects of anti-CmeA and anti-CmeB peptide nucleic acids on sensitizing Campylobacter jejuni to antibiotics

Yang Mu, Zhangqi Shen, Byeonghwa Jeon, Lei Dai, Qijing Zhang

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

The CmeABC efflux pump in Campylobacter jejuni confers resistance to structurally divergent antimicrobials, and inhibition of CmeABC represents a promising strategy to control antibiotic-resistant Campylobacter. Antisense peptide nucleic acids (PNAs) targeting the three components of CmeABC were evaluated for inhibition of CmeABC expression. The result revealed a synergistic effect of the PNAs targeting CmeA and CmeB on sensitizing C. jejuni to antibiotics. This finding further demonstrates the feasibility of using PNAs to potentiate antibiotics against antibiotic-resistant Campylobacter.

Original languageEnglish (US)
Pages (from-to)4575-4577
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume57
Issue number9
DOIs
StatePublished - Sep 2013

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