TY - JOUR
T1 - Synergistic antiproliferative activity of tumor necrosis factor alpha (TNF-α) and lovastatin
AU - Sora, M. K.
AU - Kruszewski, A. A.
AU - Stoklosa, T.
AU - Czyzyk, J.
AU - Lasek, W.
AU - Malejczyk, J.
AU - Jakobisiak, M.
PY - 1994
Y1 - 1994
N2 - We assessed the antiproliferative effect of tumor necrosis factor alpha (TNF-α) and lovastatin, an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, alone and in combination, on two murine tumor cell lines. Recombinant TNF-α inhibited proliferation of murine MmB16 melanoma cells in a concentration-dependent fashion but stimulated growth of murine L1210 leukemia cells at 0.1 ng/ml concentration. Lovastatin inhibited proliferation both of murine MmB16 melanoma cells and of murine L1210 leukemia cells in a concentration-dependent fashion. In combination with tumor necrosis factor alpha lovastatin inhibited synergistically growth of both cell lines as assessed by isobologram analysis. Our data show that lovastatin, a cholesterol synthesis inhibitor, introduced to the clinic to treat hyercholesterolemia, used either as a single agent or in combination with TNF-α inhibits growth of MmB16 melanoma and L1210 leukemia cells.
AB - We assessed the antiproliferative effect of tumor necrosis factor alpha (TNF-α) and lovastatin, an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, alone and in combination, on two murine tumor cell lines. Recombinant TNF-α inhibited proliferation of murine MmB16 melanoma cells in a concentration-dependent fashion but stimulated growth of murine L1210 leukemia cells at 0.1 ng/ml concentration. Lovastatin inhibited proliferation both of murine MmB16 melanoma cells and of murine L1210 leukemia cells in a concentration-dependent fashion. In combination with tumor necrosis factor alpha lovastatin inhibited synergistically growth of both cell lines as assessed by isobologram analysis. Our data show that lovastatin, a cholesterol synthesis inhibitor, introduced to the clinic to treat hyercholesterolemia, used either as a single agent or in combination with TNF-α inhibits growth of MmB16 melanoma and L1210 leukemia cells.
KW - antiproliferative activity
KW - lovastatin
KW - tumor necrosis factor alpha
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M3 - Article
C2 - 7487365
AN - SCOPUS:0028575409
SN - 0004-069X
VL - 42
SP - 269
EP - 274
JO - Archivum Immunologiae et Therapiae Experimentalis
JF - Archivum Immunologiae et Therapiae Experimentalis
IS - 4
ER -