Synaptic structure and function in transgenic APP mice

Karen Hsiao Ashe

doi:10.1111/j.1749-6632.2000.tb05558.x

Synaptic structure and function in transgenic APP mice

Karen Hsiao Ashe

Neurology

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Efforts using transgenic mice are being made to understand the molecular and structural basis for dementia in Alzheimer's disease. Transgenic mice 12 to 18 months of age with amyloid plaques and impaired cognition show no neuronal or synaptic loss in the CA1 hippocampal subfield. Electrophysiological studies may yield new insights.

Original language	English (US)
Pages (from-to)	39-41
Number of pages	3
Journal	Annals of the New York Academy of Sciences
Volume	924
DOIs	https://doi.org/10.1111/j.1749-6632.2000.tb05558.x
State	Published - Jan 1 2000

Keywords

Amyloid precursor protein
Synaptic structure (murine)
Transgenic APP mice

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10.1111/j.1749-6632.2000.tb05558.x

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Synaptic structure and function in transgenic APP mice

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