Synaptic structure and function in transgenic APP mice

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11 Scopus citations


Efforts using transgenic mice are being made to understand the molecular and structural basis for dementia in Alzheimer's disease. Transgenic mice 12 to 18 months of age with amyloid plaques and impaired cognition show no neuronal or synaptic loss in the CA1 hippocampal subfield. Electrophysiological studies may yield new insights.

Original languageEnglish (US)
Pages (from-to)39-41
Number of pages3
JournalAnnals of the New York Academy of Sciences
StatePublished - 2000


  • Amyloid precursor protein
  • Synaptic structure (murine)
  • Transgenic APP mice


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