Synaptic organization and ionic basis of on and off channels in mudpuppy retina: III. A model of ganglion cell receptive field organization based on chloride-free experiments

R. F. Miller, R. F. Dacheux

Research output: Contribution to journalArticlepeer-review

59 Scopus citations

Abstract

A chloride-free environment produces selective changes in the retinal network which include a separation of on and off channels. The identification of chloride-sensitive and insensitive neuronal activity permits identification of some of the connections and intervening polarities of synaptic interactions which are expressed in ganglion cell receptive field organization. These experiments support previous suggestions that surround antagonism is dependent on horizontal cell activity. In addition they suggest a model of the neuronal connections which subserve on-center, off-center, and on-off ganglion cells. Experimental tests of the on-off ganglion cell model favor the idea that this type of ganglion cell receives inhibitory input from amacrine cells and excitatory activation from depolarizing and hyperpolarizing bipolar cells.

Original languageEnglish (US)
Pages (from-to)679-690
Number of pages12
JournalJournal of General Physiology
Volume67
Issue number6
DOIs
StatePublished - Jun 1976

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