Abstract
Extracellular ganglion cell recordings in the perfused mudpuppy eyecup show that a chloride-free (c-f) perfusate abolishes the center and surround excitation of on-center cells, the surround excitation of off-center cells, and the on discharge of on-off cells. These changes in ganglion cell receptive field organization are anticipated in view of the effects of a c-f environment on the neqrons which are presynaptic to the ganglion cells. However, chloride-dependent inhibitory postsynaptic (IPS) responses have been observed in on-off ganglion cells. These inhibitory postsynaptic potentials (IPSP’s) are preceded by (EPSP’s) excitatory postsynaptic potentials and are apparently mediated by amacrine cells. The light-activated hyperpolarization of off cells is not the result of a chloride-dependent IPSP and probably results from disfacilitation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 661-678 |
| Number of pages | 18 |
| Journal | Journal of General Physiology |
| Volume | 67 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jun 1 1976 |
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Synaptic organization and ionic basis of on and off channels in mudpuppy retina : II. Chloride-dependent ganglion cell mechanisms. / Miller, Robert F.; Dacheux, Ramon F.
In: Journal of General Physiology, Vol. 67, No. 6, 01.06.1976, p. 661-678.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Synaptic organization and ionic basis of on and off channels in mudpuppy retina
T2 - II. Chloride-dependent ganglion cell mechanisms
AU - Miller, Robert F.
AU - Dacheux, Ramon F.
PY - 1976/6/1
Y1 - 1976/6/1
N2 - Extracellular ganglion cell recordings in the perfused mudpuppy eyecup show that a chloride-free (c-f) perfusate abolishes the center and surround excitation of on-center cells, the surround excitation of off-center cells, and the on discharge of on-off cells. These changes in ganglion cell receptive field organization are anticipated in view of the effects of a c-f environment on the neqrons which are presynaptic to the ganglion cells. However, chloride-dependent inhibitory postsynaptic (IPS) responses have been observed in on-off ganglion cells. These inhibitory postsynaptic potentials (IPSP’s) are preceded by (EPSP’s) excitatory postsynaptic potentials and are apparently mediated by amacrine cells. The light-activated hyperpolarization of off cells is not the result of a chloride-dependent IPSP and probably results from disfacilitation.
AB - Extracellular ganglion cell recordings in the perfused mudpuppy eyecup show that a chloride-free (c-f) perfusate abolishes the center and surround excitation of on-center cells, the surround excitation of off-center cells, and the on discharge of on-off cells. These changes in ganglion cell receptive field organization are anticipated in view of the effects of a c-f environment on the neqrons which are presynaptic to the ganglion cells. However, chloride-dependent inhibitory postsynaptic (IPS) responses have been observed in on-off ganglion cells. These inhibitory postsynaptic potentials (IPSP’s) are preceded by (EPSP’s) excitatory postsynaptic potentials and are apparently mediated by amacrine cells. The light-activated hyperpolarization of off cells is not the result of a chloride-dependent IPSP and probably results from disfacilitation.
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UR - http://www.scopus.com/inward/citedby.url?scp=0017071234&partnerID=8YFLogxK
U2 - 10.1085/jgp.67.6.661
DO - 10.1085/jgp.67.6.661
M3 - Article
C2 - 932669
AN - SCOPUS:0017071234
VL - 67
SP - 661
EP - 678
JO - Journal of General Physiology
JF - Journal of General Physiology
SN - 0022-1295
IS - 6
ER -