Synaptic organization and ionic basis of on and off channels in mudpuppy retina: II. Chloride-dependent ganglion cell mechanisms

Robert F. Miller, Ramon F. Dacheux

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Extracellular ganglion cell recordings in the perfused mudpuppy eyecup show that a chloride-free (c-f) perfusate abolishes the center and surround excitation of on-center cells, the surround excitation of off-center cells, and the on discharge of on-off cells. These changes in ganglion cell receptive field organization are anticipated in view of the effects of a c-f environment on the neqrons which are presynaptic to the ganglion cells. However, chloride-dependent inhibitory postsynaptic (IPS) responses have been observed in on-off ganglion cells. These inhibitory postsynaptic potentials (IPSP’s) are preceded by (EPSP’s) excitatory postsynaptic potentials and are apparently mediated by amacrine cells. The light-activated hyperpolarization of off cells is not the result of a chloride-dependent IPSP and probably results from disfacilitation.

Original languageEnglish (US)
Pages (from-to)661-678
Number of pages18
JournalJournal of General Physiology
Volume67
Issue number6
DOIs
StatePublished - Jun 1 1976

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Necturus
Ganglia
Retina
Chlorides
Inhibitory Postsynaptic Potentials
Excitatory Postsynaptic Potentials
Amacrine Cells
Light

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Synaptic organization and ionic basis of on and off channels in mudpuppy retina : II. Chloride-dependent ganglion cell mechanisms. / Miller, Robert F.; Dacheux, Ramon F.

In: Journal of General Physiology, Vol. 67, No. 6, 01.06.1976, p. 661-678.

Research output: Contribution to journalArticle

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