Abstract
Extracellular ganglion cell recordings in the perfused mudpuppy eyecup show that a chloride-free (c-f) perfusate abolishes the center and surround excitation of on-center cells, the surround excitation of off-center cells, and the on discharge of on-off cells. These changes in ganglion cell receptive field organization are anticipated in view of the effects of a c-f environment on the neqrons which are presynaptic to the ganglion cells. However, chloride-dependent inhibitory postsynaptic (IPS) responses have been observed in on-off ganglion cells. These inhibitory postsynaptic potentials (IPSP’s) are preceded by (EPSP’s) excitatory postsynaptic potentials and are apparently mediated by amacrine cells. The light-activated hyperpolarization of off cells is not the result of a chloride-dependent IPSP and probably results from disfacilitation.
Original language | English (US) |
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Pages (from-to) | 661-678 |
Number of pages | 18 |
Journal | Journal of General Physiology |
Volume | 67 |
Issue number | 6 |
DOIs | |
State | Published - Jun 1 1976 |