Symptom Clusters, Physical Activity, and Quality of Life: A Latent Class Analysis of Children during Maintenance Therapy for Leukemia

Mary C. Hooke; Michelle A. Mathiason; Audrey Blommer; Jessica Hutter; Pauline Mitby; Olga Taylor; Michael E. Scheurer; Alicia S. Kunin-Batson; Wei Pan; Marilyn J. Hockenberry

doi:10.1097/ncc.0000000000000963

Symptom Clusters, Physical Activity, and Quality of Life: A Latent Class Analysis of Children during Maintenance Therapy for Leukemia

Mary C. Hooke, Michelle A. Mathiason, Audrey Blommer, Jessica Hutter, Pauline Mitby, Olga Taylor, Michael E. Scheurer, Alicia S. Kunin-Batson, Wei Pan, Marilyn J. Hockenberry

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

BACKGROUND: Children undergoing treatment for acute lymphocytic leukemia (ALL) report co-occurring symptoms of fatigue, sleep disturbances, and depression as a symptom cluster. Physical activity (PA) may influence symptom severity and quality of life (QOL).

OBJECTIVES: This study examined changes in symptoms and QOL during ALL maintenance in children categorized by symptom cluster and explored the influence of PA and symptoms on QOL.

METHODS: Self-report of fatigue, sleep disturbance, and depression; QOL; and PA were measured at the beginning and end of maintenance in 42 children aged 3 to 18 years with ALL. Children were categorized into symptom cluster groups based on measurements at the beginning of maintenance.

RESULTS: Two latent classes of symptom clusters (low and high) were identified with significant differences between groups in symptoms at both the beginning and end maintenance (P < .01). Each group's symptom levels did not change during maintenance. Quality-of-life was different between groups at both time points (P < .01) and did not improve. Children with low symptoms and high PA at the beginning of maintenance had better QOL as treatment ended compared with the physically active high-symptom group and the inactive high-symptom group (P < .01).

CONCLUSIONS: Children with higher symptoms did not experience an improvement with time. Symptom and PA levels may influence QOL at the end of treatment.

IMPLICATIONS FOR PRACTICE: Maintenance therapy is a long time (1.5 years) in a child's life. Symptom assessment is needed early in maintenance; interventions are needed for children with high levels.

Original language	English (US)
Pages (from-to)	113-119
Number of pages	7
Journal	Cancer Nursing
Volume	45
Issue number	2
DOIs	https://doi.org/10.1097/ncc.0000000000000963
State	Published - 2022

Bibliographical note

Funding Information:
This work was supported by a grant from the Arthur Olofson Medical Research Fund at the University of Minnesota Foundation and National Institutes of Health R01CA1693398.

Publisher Copyright:
© Wolters Kluwer Health, Inc. All rights reserved.

Keywords

Childhood leukemia
Latent class analysis
Maintenance therapy
Physical activity
Quality of life
Symptom clusters

PubMed: MeSH publication types

Journal Article

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Publisher link

10.1097/ncc.0000000000000963

Find It

Find It at U of M Libraries

Cite this

@article{27c628368b214a4496e196237de670a9,

title = "Symptom Clusters, Physical Activity, and Quality of Life: A Latent Class Analysis of Children during Maintenance Therapy for Leukemia",

abstract = "BACKGROUND: Children undergoing treatment for acute lymphocytic leukemia (ALL) report co-occurring symptoms of fatigue, sleep disturbances, and depression as a symptom cluster. Physical activity (PA) may influence symptom severity and quality of life (QOL).OBJECTIVES: This study examined changes in symptoms and QOL during ALL maintenance in children categorized by symptom cluster and explored the influence of PA and symptoms on QOL.METHODS: Self-report of fatigue, sleep disturbance, and depression; QOL; and PA were measured at the beginning and end of maintenance in 42 children aged 3 to 18 years with ALL. Children were categorized into symptom cluster groups based on measurements at the beginning of maintenance.RESULTS: Two latent classes of symptom clusters (low and high) were identified with significant differences between groups in symptoms at both the beginning and end maintenance (P < .01). Each group's symptom levels did not change during maintenance. Quality-of-life was different between groups at both time points (P < .01) and did not improve. Children with low symptoms and high PA at the beginning of maintenance had better QOL as treatment ended compared with the physically active high-symptom group and the inactive high-symptom group (P < .01).CONCLUSIONS: Children with higher symptoms did not experience an improvement with time. Symptom and PA levels may influence QOL at the end of treatment.IMPLICATIONS FOR PRACTICE: Maintenance therapy is a long time (1.5 years) in a child's life. Symptom assessment is needed early in maintenance; interventions are needed for children with high levels.",

keywords = "Childhood leukemia, Latent class analysis, Maintenance therapy, Physical activity, Quality of life, Symptom clusters",

author = "Hooke, {Mary C.} and Mathiason, {Michelle A.} and Audrey Blommer and Jessica Hutter and Pauline Mitby and Olga Taylor and Scheurer, {Michael E.} and Kunin-Batson, {Alicia S.} and Wei Pan and Hockenberry, {Marilyn J.}",

note = "Funding Information: This work was supported by a grant from the Arthur Olofson Medical Research Fund at the University of Minnesota Foundation and National Institutes of Health R01CA1693398. Publisher Copyright: {\textcopyright} Wolters Kluwer Health, Inc. All rights reserved.",

year = "2022",

doi = "10.1097/ncc.0000000000000963",

language = "English (US)",

volume = "45",

pages = "113--119",

journal = "Cancer Nursing",

issn = "0162-220X",

publisher = "Lippincott Williams and Wilkins Ltd.",

number = "2",

}

TY - JOUR

T1 - Symptom Clusters, Physical Activity, and Quality of Life

T2 - A Latent Class Analysis of Children during Maintenance Therapy for Leukemia

AU - Hooke, Mary C.

AU - Mathiason, Michelle A.

AU - Blommer, Audrey

AU - Hutter, Jessica

AU - Mitby, Pauline

AU - Taylor, Olga

AU - Scheurer, Michael E.

AU - Kunin-Batson, Alicia S.

AU - Pan, Wei

AU - Hockenberry, Marilyn J.

N1 - Funding Information: This work was supported by a grant from the Arthur Olofson Medical Research Fund at the University of Minnesota Foundation and National Institutes of Health R01CA1693398. Publisher Copyright: © Wolters Kluwer Health, Inc. All rights reserved.

PY - 2022

Y1 - 2022

N2 - BACKGROUND: Children undergoing treatment for acute lymphocytic leukemia (ALL) report co-occurring symptoms of fatigue, sleep disturbances, and depression as a symptom cluster. Physical activity (PA) may influence symptom severity and quality of life (QOL).OBJECTIVES: This study examined changes in symptoms and QOL during ALL maintenance in children categorized by symptom cluster and explored the influence of PA and symptoms on QOL.METHODS: Self-report of fatigue, sleep disturbance, and depression; QOL; and PA were measured at the beginning and end of maintenance in 42 children aged 3 to 18 years with ALL. Children were categorized into symptom cluster groups based on measurements at the beginning of maintenance.RESULTS: Two latent classes of symptom clusters (low and high) were identified with significant differences between groups in symptoms at both the beginning and end maintenance (P < .01). Each group's symptom levels did not change during maintenance. Quality-of-life was different between groups at both time points (P < .01) and did not improve. Children with low symptoms and high PA at the beginning of maintenance had better QOL as treatment ended compared with the physically active high-symptom group and the inactive high-symptom group (P < .01).CONCLUSIONS: Children with higher symptoms did not experience an improvement with time. Symptom and PA levels may influence QOL at the end of treatment.IMPLICATIONS FOR PRACTICE: Maintenance therapy is a long time (1.5 years) in a child's life. Symptom assessment is needed early in maintenance; interventions are needed for children with high levels.

AB - BACKGROUND: Children undergoing treatment for acute lymphocytic leukemia (ALL) report co-occurring symptoms of fatigue, sleep disturbances, and depression as a symptom cluster. Physical activity (PA) may influence symptom severity and quality of life (QOL).OBJECTIVES: This study examined changes in symptoms and QOL during ALL maintenance in children categorized by symptom cluster and explored the influence of PA and symptoms on QOL.METHODS: Self-report of fatigue, sleep disturbance, and depression; QOL; and PA were measured at the beginning and end of maintenance in 42 children aged 3 to 18 years with ALL. Children were categorized into symptom cluster groups based on measurements at the beginning of maintenance.RESULTS: Two latent classes of symptom clusters (low and high) were identified with significant differences between groups in symptoms at both the beginning and end maintenance (P < .01). Each group's symptom levels did not change during maintenance. Quality-of-life was different between groups at both time points (P < .01) and did not improve. Children with low symptoms and high PA at the beginning of maintenance had better QOL as treatment ended compared with the physically active high-symptom group and the inactive high-symptom group (P < .01).CONCLUSIONS: Children with higher symptoms did not experience an improvement with time. Symptom and PA levels may influence QOL at the end of treatment.IMPLICATIONS FOR PRACTICE: Maintenance therapy is a long time (1.5 years) in a child's life. Symptom assessment is needed early in maintenance; interventions are needed for children with high levels.

KW - Childhood leukemia

KW - Latent class analysis

KW - Maintenance therapy

KW - Physical activity

KW - Quality of life

KW - Symptom clusters

UR - http://www.scopus.com/inward/record.url?scp=85124805077&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85124805077&partnerID=8YFLogxK

U2 - 10.1097/ncc.0000000000000963

DO - 10.1097/ncc.0000000000000963

M3 - Article

C2 - 34387237

AN - SCOPUS:85124805077

SN - 0162-220X

VL - 45

SP - 113

EP - 119

JO - Cancer Nursing

JF - Cancer Nursing

IS - 2

ER -

Symptom Clusters, Physical Activity, and Quality of Life: A Latent Class Analysis of Children during Maintenance Therapy for Leukemia

Abstract

Bibliographical note

Keywords

PubMed: MeSH publication types

UN SDGs

Publisher link

Find It

Other files and links

Fingerprint

Cite this