Sweet Sulfamethazine Acesulfamate Crystals with Improved Compaction Property

Sibo Liu, Chenguang Wang, Hongbo Chen, Changquan Calvin Sun

Research output: Contribution to journalArticlepeer-review


Sulfamethazine (SMT) is a sulfonamide antibacterial drug used to treat or prevent infections in both humans and animals. However, SMT exhibits unfavorable taste and poor compaction behavior. To overcome these problems, a 1:1 complex with an artificial sweetener, acesulfame (Acs), was prepared and characterized. The single crystal structure suggested that the new complex, SMT-Acs, is a salt. This was confirmed by an analysis of C-N bond length in comparison to those of multicomponent SMT crystals with known ionization states of SMT and Fourier transformation infrared spectroscopy. SMT-Acs exhibits better tabletability than SMT, due to its greater plasticity as shown by Heckel and Kuentz-Leuenberger analyses. The greater plasticity of SMT-Acs is consistent with the presence of slip planes identified by combined energy framework and topological analysis of the crystal structures.

Original languageEnglish (US)
Pages (from-to)1077-1085
Number of pages9
JournalCrystal Growth and Design
Issue number2
StatePublished - Feb 3 2021

Bibliographical note

Funding Information:
We thank the Minnesota Supercomputing Institute (MSI) at the University of Minnesota for providing resources that contributed to the research results reported in this paper ( http://www.msi.umn.edu ). The Bruker-AXS D8 Venture diffractometer was purchased through a grant from NSF/MRI (#1229400) and the University of Minnesota.

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