Sustained transscleral drug delivery

Victor H Barocas, Ram K. Balachandran

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

Transscleral delivery is an emerging, high-potential method for delivering drugs to the posterior eye. If successful, it could offer non-invasiveness comparable to drops and delivery efficiency comparable to intravitreal injection. However, there are numerous challenges to be overcome before transscleral delivery will be a significant treatment option. The resistance of the sclera is extremely well understood, but the other tissues, especially the retinal pigment epithelium, clearly demand more attention and the effect of drug chemistry remains poorly understood. In this review, the major research on transscleral delivery with an emphasis on current understanding of these points and open questions for the field is summarized.

Original languageEnglish (US)
Pages (from-to)1-10
Number of pages10
JournalExpert Opinion on Drug Delivery
Volume5
Issue number1
DOIs
StatePublished - Jan 1 2008

Fingerprint

Sclera
Intravitreal Injections
Retinal Pigment Epithelium
Pharmaceutical Preparations
Research
Therapeutics

Keywords

  • Age-related macular degeneration
  • Drug delivery
  • Ophthalmology
  • Retinal pigment epithelium
  • Sclera

Cite this

Sustained transscleral drug delivery. / Barocas, Victor H; Balachandran, Ram K.

In: Expert Opinion on Drug Delivery, Vol. 5, No. 1, 01.01.2008, p. 1-10.

Research output: Contribution to journalReview article

Barocas, Victor H ; Balachandran, Ram K. / Sustained transscleral drug delivery. In: Expert Opinion on Drug Delivery. 2008 ; Vol. 5, No. 1. pp. 1-10.
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