Sustained remission of severe multicentric castleman disease following multiagent chemotherapy and tocilizumab maintenance

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Castleman disease is a rare lymphoproliferative disorder, which presents in a unicentric or multicentric fashion. Multicentric Castleman disease (MCD) is associated with significant systemic symptoms, in part related to the underlying role of interleukin-6 in disease pathogenesis. Treatment for MCD has not been well established and prognosis has historically been poor. We present a case of severe MCD in a pediatric patient who has shown sustained remission following multi-agent chemotherapy and targeted maintenance therapy with the interleukin-6 receptor inhibitor, tocilizumab. This represents the first case report of sustained remission of MCD in a pediatric patient following discontinuation of tocilizumab therapy.

Original languageEnglish (US)
Pages (from-to)737-739
Number of pages3
JournalPediatric Blood and Cancer
Volume61
Issue number4
DOIs
StatePublished - Apr 2014

Keywords

  • Anakinra
  • CHOP
  • Multicentric Castleman disease
  • Tocilizumab

Fingerprint Dive into the research topics of 'Sustained remission of severe multicentric castleman disease following multiagent chemotherapy and tocilizumab maintenance'. Together they form a unique fingerprint.

Cite this