Sustained Oncogenic Signaling in the Cytostatic State Enables Targeting of Nonproliferating Persistent Cancer Cells

Keyphrases

• Advanced Therapeutics 8%
• Akt Activation 8%
• AKT Pathway 16%
• Breast Cancer Subtypes 8%
• Cancer Cell Growth 8%
• Cancer Cell Populations 16%
• Cancer Cells 58%
• Cancer Recurrence 16%
• Cell Viability 8%
• Current Management 8%
• Cytostatic 100%
• Cytostatic Agents 8%
• Cytostatic Therapy 8%
• Drug Resistance 8%
• Epithelial Cells 8%
• Epithelial Origin 8%
• Homeostasis 8%
• Induced Apoptosis 8%
• Management Approach 8%
• Mouse Model 8%
• Oncogenic Signaling 100%
• Organotypic Model 8%
• Pathway mutation 16%
• Persistent Cancer Cells 100%
• PI3K Pathway 16%
• Proteasome Inhibition 8%
• Proteotoxic 8%
• Recurrent Tumor 8%
• Resistant Clones 8%
• Spheroid Model 8%
• Targeted Therapy 8%
• Therapeutic Potential 8%
• Treatment Conditions 8%
• Tumor Growth 8%
• Vulnerability 25%

Medicine and Dentistry

• Breast Cancer 7%
• Cancer Cell 100%
• Cancer Growth 7%
• Cancer Recurrence 15%
• Carcinogenesis 100%
• Cell Population 15%
• Cell Viability 7%
• Cytostatic 100%
• Cytostatic Agent 7%
• Drug Resistance 7%
• Epithelial Cell 7%
• Homeostasis 7%
• Programmed Cell Death 7%
• Proteasome 38%
• Protein Kinase B 46%
• Targeted Therapy 7%
• Tumor Progression 7%
• Tumor Recurrence 7%
• Tumor Spheroid 7%

Pharmacology, Toxicology and Pharmaceutical Science

• Breast Cancer 7%
• Cancer Growth 7%
• Cancer Recurrence 15%
• Carcinogenesis 100%
• Cell Viability 7%
• Cytostatic 100%
• Cytostatic Agent 7%
• Drug Resistance 7%
• Malignant Neoplasm 100%
• Mouse Model 7%
• Proteasome 38%
• Protein Kinase B 46%
• Tumor Growth 7%
• Tumor Recurrence 7%