Sustained engraftment and resolution of bleeding phenotype after unrelated cord blood hematopoietic stem cell transplantation for severe Glanzmann thrombasthenia

Weston P Miller, Amy Dunn, Kuang Yueh Chiang

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Glanzmann thrombasthenia is a rare, autosomal recessive, qualitative platelet disorder resulting from abnormal platelet surface glycoprotein IIb/IIIa. In phenotypically severe cases, medical management is often challenging. Although definitive hemostasis can be achieved with platelet transfusion, alloimmunization and subsequent platelet refractoriness remain a real risk. To date, only hematopoietic stem cell transplantation has been curative; however, suitable donor availability can be a barrier for some patients. We are the first to report the use of umbilical cord blood hematopoietic stem cell transplantation for Glanzmann thrombasthenia.

Original languageEnglish (US)
Pages (from-to)437-439
Number of pages3
JournalJournal of pediatric hematology/oncology
Volume31
Issue number6
DOIs
StatePublished - Jun 1 2009

Keywords

  • Glanzmann thrombasthenia
  • Hematopoietic stem cell transplantation
  • Umbilical cord blood transplantation

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