Abstract
Neutropenic fever is a common complication of myelosuppressive therapy in pediatric oncology patients. Piperacillin-tazobactam (PIP/TAZO) is a broad spectrum antibiotic used for empiric treatment of neutropenic fever. We describe four cases of suspected PIP/TAZO induced nephrotoxicity occurring in children with pediatric malignancies admitted to the hospital and treated for fever±neutropenia. All patients exhibited acute renal injury shortly after PIP/TAZO administration with one of these cases having biopsy evidence of acute interstitial nephritis. These findings are suggestive of PIP/TAZO induced nephrotoxicity in pediatric oncology patients with fever±neutropenia and that PIP/TAZO should be used judiciously in this population.
Original language | English (US) |
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Pages (from-to) | 366-368 |
Number of pages | 3 |
Journal | Pediatric Blood and Cancer |
Volume | 61 |
Issue number | 2 |
DOIs | |
State | Published - Feb 2014 |
Keywords
- Nephrotoxicity
- Oncology
- Piperacillin-tazobactam