Susceptibility of multidrug-resistant gram-negative urine isolates to oral antibiotics

Elizabeth B. Hirsch, Paola C. Zucchi, Alice Chen, Brian R. Raux, James E. Kirby, Christopher McCoy, George M. Eliopoulos

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


Increasing resistance among Gram-negative uropathogens limits treatment options, and susceptibility data for multidrug-resistant isolates are limited. We assessed the activity of five oral agents against 91 multidrug-resistant Gram-negative urine isolates that were collected from emergency department/hospitalized patients. Fosfomycin and nitrofurantoin were most active (>75% susceptibility). Susceptibilities to sulfamethoxazole-trimethoprim, ciprofloxacin, and ampicillin were ≤ 40%; empirical use of these agents likely provides inadequate coverage in areas with a high prevalence of multidrug-resistant uropathogens.

Original languageEnglish (US)
Pages (from-to)3138-3140
Number of pages3
JournalAntimicrobial agents and chemotherapy
Issue number5
StatePublished - May 2016

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Copyright © 2016, American Society for Microbiology. All Rights Reserved.


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