Survival of lung cancer patients dependent on the loh status for dmp1, arf, and p53

Elizabeth A. Fry, Gloria A Niehans, Robert A. Kratzke, Fumitake Kai, Kazushi Inoue

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Lung cancer is the leading cause of cancer deaths in the world, and accounts for more solid tumor deaths than any other carcinomas. The prognostic values of DMP1, ARF, and p53-loss are unknown in lung cancer. We have conducted survival analyses of non-small cell lung cancer (NSCLC) patients from the University of Minnesota VA hospital and those from the Wake Forest University Hospital. Loss of Heterozygosity (LOH) for hDMPl was found in 26 of 70 cases (37.1%), that of the ARF/INK4a locus was found in 33 of 70 (47.1%), and that of the p53 locus in 43 cases (61.4%) in the University of Minnesota samples. LOH for hDMPl was associated with favorable prognosis while that of p53 predicted worse prognosis. The survival was much shorter for ARF-loss than INK4a-loss, emphasizing the importance of ARF in human NSCLC. The adverse effect of p53 LOH on NSCLC patients survival was neutralized by simultaneous loss of the hDMPl locus in NSCLC and breast cancer, suggesting the possible therapy of epithelial cancers with metastatic ability.

Original languageEnglish (US)
Article number7971
Pages (from-to)1-16
Number of pages16
JournalInternational journal of molecular sciences
Volume21
Issue number21
DOIs
StatePublished - Nov 1 2020

Bibliographical note

Funding Information:
Funding: K.I. was supported by NIH/NCI 2R01CA106314, ACS RSG-07-207-01-MGO, and KG080179.

Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

  • ARF
  • Cyclin D1
  • DMTF1
  • INK4a
  • P53
  • YY1

PubMed: MeSH publication types

  • Journal Article

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