Surgical swine model of chronic cardiac ischemia treated by off-pump coronary artery bypass graft surgery

Laura L Hocum Stone, Christin Wright, Erin Chappuis, Mia Messer, Herbert B Ward, Edward O McFalls, Rosemary F Kelly

Research output: Contribution to journalArticle

Abstract

Chronic cardiac ischemia that impairs cardiac function, but does not result in infarct, is termed hibernating myocardium (HM). A large clinical subset of coronary artery disease (CAD) patients have HM, which in addition to causing impaired function, puts them at higher risk for arrhythmia and future cardiac events. The standard treatment for this condition is revascularization, but this has been shown to be an imperfect therapy. The majority of pre-clinical cardiac research focuses on infarct models of cardiac ischemia, leaving this subset of chronic ischemia patients largely underserved. To address this gap in research, we have developed a well-characterized and highly reproducible model of hibernating myocardium in swine, as swine are ideal translational models for human heart disease. In addition to creating this unique disease model, we have optimized a clinically relevant treatment model of coronary artery bypass surgery in swine. This allows us to accurately study the effects of bypass surgery on heart disease, as well as investigate additional or alternate therapies. This model surgically induces single vessel stenosis by implanting a constrictor on the left anterior descending (LAD) artery in a young pig. As the pig grows, the constrictor creates a gradual stenosis, resulting in chronic ischemia with impaired regional function, but preserving tissue viability. Following the establishment of the hibernating myocardium phenotype, we perform off-pump coronary artery bypass graft surgery to revascularize the ischemic region, mimicking the gold-standard treatment for patients in the clinic.

Original languageEnglish (US)
Article numbere57229
JournalJournal of Visualized Experiments
Volume2018
Issue number133
DOIs
StatePublished - Mar 14 2018

Fingerprint

Off-Pump Coronary Artery Bypass
Anatomic Models
Grafts
Coronary Artery Bypass
Surgery
Swine
Ischemia
Pumps
Myocardium
Transplants
Heart Diseases
Pathologic Constriction
Therapeutics
Tissue Survival
Vulnerable Populations
Research
Gold
Cardiac Arrhythmias
Coronary Artery Disease
Arteries

Keywords

  • Coronary artery bypass graft
  • Hibernating myocardium
  • Ischemia
  • Revascularization
  • Surgical model
  • Swine

Cite this

Surgical swine model of chronic cardiac ischemia treated by off-pump coronary artery bypass graft surgery. / Hocum Stone, Laura L; Wright, Christin; Chappuis, Erin; Messer, Mia; Ward, Herbert B; McFalls, Edward O; Kelly, Rosemary F.

In: Journal of Visualized Experiments, Vol. 2018, No. 133, e57229, 14.03.2018.

Research output: Contribution to journalArticle

Hocum Stone, Laura L ; Wright, Christin ; Chappuis, Erin ; Messer, Mia ; Ward, Herbert B ; McFalls, Edward O ; Kelly, Rosemary F. / Surgical swine model of chronic cardiac ischemia treated by off-pump coronary artery bypass graft surgery. In: Journal of Visualized Experiments. 2018 ; Vol. 2018, No. 133.
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