Surfactant delivery strategies to prevent bronchopulmonary dysplasia

Angela Kribs, Kari D. Roberts, Daniele Trevisanuto, Colm O'Donnell, Peter A. Dargaville

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Bronchopulmonary dysplasia (BPD) is one of the most devastating morbidities of preterm infants. Antenatal factors like growth restriction and inflammation are risk factors for its development. Use of oxygen and positive pressure ventilation, which are often necessary to treat respiratory distress syndrome (RDS), increase the risk for development of BPD. Continuous positive airway pressure (CPAP) as primary respiratory support allows for avoidance of positive pressure ventilation in many cases but may lead to a delay of surfactant administration which is a proven therapy for RDS. Several alternative surfactant delivery strategies, including nebulization of surfactant, pharyngeal instillation of surfactant, delivery of surfactant via supraglottic airway device or surfactant delivery via a thin endotracheal catheter have been described which allow for the benefit of surfactant therapy while on CPAP. This review reports available data and discusses the existing evidence of their value in preventing BPD as well as further research directions.

Original languageEnglish (US)
Article number151813
JournalSeminars in Perinatology
Issue number6
StatePublished - Oct 2023

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© 2023


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PubMed: MeSH publication types

  • Review
  • Journal Article


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