Surface protein expression in Group B streptococcal invasive isolates

Patricia Ferrieri, Aurea E. Flores

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


Results from characterization of 211 GBS isolates from early-onset disease indicated that serotypes Ia, III and V accounted for almost 80% of the isolates, and that α was the protein most often expressed. Each of the common polysaccharide types had a characteristic predominant protein expression pattern: α for Ia, R4 for type III and R1 + R4 for type V isolates. Expression of α protein was always mutually exclusive of R proteins. The presence of more than one species of R by a given isolate was confirmed by IEP. In addition, PAGE/WB studies verified the multiple MW forms of R1, and the variation from strain to strain in the highest form of R4 that we had previously reported. Our data not only showed the great complexity of the GBS cell surface but also demonstrated that advantage of using both type polysaccharides and surface-localized proteins as markers for characterization of GBS strains.

Original languageEnglish (US)
Pages (from-to)635-637
Number of pages3
JournalAdvances in experimental medicine and biology
StatePublished - 1997


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