Surface modification of nanoparticles: Methods and applications

Gopi Krishna Moku, Vijayagopal Raman Gopalsamuthiram, Thomas R. Hoye, Jayanth Panyam

Research output: Chapter in Book/Report/Conference proceedingChapter

19 Scopus citations


This chapter discusses the various polymers used in the formulation of nanoparticles, fabrication and characterization techniques, surface modification methods, and the different types of targeting ligands that have been evaluated. Characterization of nanoparticles for size, morphology, and surface charge has been done using various microscopic techniques including scanning electron microscopy, and transmission electron microscopy. These techniques have also been used to understand the variation in the physical properties of particles after surface modification. The average particle diameter, their size distribution, and charge affect the physical stability and their in vivo distribution. Electron microscopy techniques are very useful in ascertaining the overall shape of polymeric nanoparticles, parameters that influence their safety and biodistribution. The surface charge of nanoparticles affects the physical stability and redispersibility of the polymer dispersion as well as their in vivo performance. Many techniques have been used to study the surface modification of nanoparticles.

Original languageEnglish (US)
Title of host publicationSurface Modification of Polymers
Subtitle of host publicationMethods and Applications
Number of pages30
ISBN (Electronic)9783527819249
ISBN (Print)9783527345410
StatePublished - Dec 4 2019

Bibliographical note

Publisher Copyright:
© 2020 Wiley-VCH Verlag GmbH & Co. KGaA.


  • Biodegradable polymers
  • Characterization techniques
  • Drug delivery applications
  • Nanoparticle fabrication
  • Scanning electron microscopy
  • Surface modification methods
  • Surface-modified nanoparticles
  • Transmission electron microscopy


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