Supratherapeutic Antibiotic Levels and Acute Kidney Injury from Absorption of Topical Antibiotics: A Case Report

Michael W. Schmitz, Robert D. Wojahn

Research output: Contribution to journalArticlepeer-review

Abstract

CASE: A 96-year-old woman with no baseline renal dysfunction presented with a distal femoral shaft fracture after a ground-level fall. Treatment was with a retrograde intramedullary nail and included placement of topical antibiotics. Postoperatively, she developed acute kidney injury and was found to have supratherapeutic antibiotic levels. CONCLUSION: This case report demonstrates the risk of clinically relevant systemic absorption along with associated downstream end organ damage with the use of topical antibiotics in certain circumstances. We present this case as an illustration of a rare hazard associated with topical antibiotic use.

Original languageEnglish (US)
JournalJBJS case connector
Volume12
Issue number2
StatePublished - Apr 1 2022

Bibliographical note

Publisher Copyright:
Copyright © 2022 by The Journal of Bone and Joint Surgery, Incorporated.

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