Supramolecular materials comprising nucleic acid biopolymers

Wirasak Smitthipong, Thorsten Neumann, Arkadiusz Chworos, Luc Jaeger, Matthew Tirrell

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

We have generated a supramolecular self-assembling film by exchanging the counter-ions of the phosphate moieties in nucleic acid with those of cationic amphiphiles as didodecyldimethylammonium bromide (or DDAB). SAXS and WAXS data for all film samples showed similar harmonic peaks suggesting a lamellar multilayer structure with layers of nucleic acids being separated by lipid bilayers of DDAB. AFM height images also showed that double stranded nucleic acid film can form the step or plateau type of structure and shorter nucleic acid film showed shorter step feature. Moreover, the length and the molecular structure of DMA and RNA can be used to manipulate the mechanical properties of these self-assembled films.

Original languageEnglish (US)
Pages (from-to)13-17
Number of pages5
JournalMacromolecular Symposia
Volume264
Issue number1
DOIs
StatePublished - Mar 2008
Externally publishedYes

Keywords

  • Biomaterials
  • Biopolymers
  • Self-assembly
  • Supramolecular structures

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