Supraesophageal reflux: Validation of a symptom questionnaire

E. Dauer, D. Thompson, A. R. Zinsmeister, R. Dierkhising, A. Harris, T. Zais, J. Alexander, J. A. Murray, J. L. Wise, K. Lim, G. R. Locke, Yvonne Romero

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


OBJECTIVE: To develop and validate a questionnaire for supraesophageal manifestations of reflux (SER) that will facilitate its study in clinical and research settings. STUDY DESIGN: The Supraesophageal Reflux Questionnaire (SERQ) and previously validated Reflux Symptom Index (RSI) were subjected to multiple types of validity testing, including content validity, concurrent validity, reproducibility, and predictive validity. RESULTS: The concurrent validity and reproducibility of both instruments was good to excellent for most items tested. The predictive validity of the SERQ was superior to the RSI when it included the covariates of history of sinusitis, use of over-the-counter antacid medications, age, gender, and body mass index. CONCLUSIONS: The SERQ will serve as both a useful clinical and research tool by offering not only SER symptom information, like the RSI, but also information about the patient's medical history and medication usage that will facilitate use of the SERQ in research protocols. EBM rating: B-2b.

Original languageEnglish (US)
Pages (from-to)73-80
Number of pages8
JournalOtolaryngology - Head and Neck Surgery
Issue number1
StatePublished - Jan 2006
Externally publishedYes

Bibliographical note

Funding Information:
This work was supported by an AstraZeneca Investigator Initiated Award.


Dive into the research topics of 'Supraesophageal reflux: Validation of a symptom questionnaire'. Together they form a unique fingerprint.

Cite this