Suppression of the Mixed Leukocyte Reaction by Serum from Polynucleotide-Injected Mice

Marilyn J. Odean, Arthur G. Johnson, Sidney E. Grossberg

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Sera from mice which have been injected iv with either poly(A) · poly(U) or poly(I) · poly(C) 1 1/2 hr prior to bleeding were found to suppress the mixed lymphocyte reaction. This effect was reduced considerably by 18 hr. Characterization of the suppressive sera revealed it (a) was stable to heating at 56°C for 1 hr and freezing at −20°C for 1 month; (b) had a molecular weight greater than 30,000; (c) could be induced in sera from athymic nude mice; and (d) was present to a lower degree in sera from aging mice.

Original languageEnglish (US)
Pages (from-to)504-508
Number of pages5
JournalProceedings of the Society for Experimental Biology and Medicine
Volume179
Issue number4
DOIs
StatePublished - Sep 1985

Fingerprint Dive into the research topics of 'Suppression of the Mixed Leukocyte Reaction by Serum from Polynucleotide-Injected Mice'. Together they form a unique fingerprint.

  • Cite this