Suppression of the Mixed Leukocyte Reaction by Serum from Polynucleotide-Injected Mice

Marilyn J Odean, Arthur G Johnson, Sidney E. Grossberg

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Sera from mice which have been injected iv with either poly(A) · poly(U) or poly(I) · poly(C) 1 1/2 hr prior to bleeding were found to suppress the mixed lymphocyte reaction. This effect was reduced considerably by 18 hr. Characterization of the suppressive sera revealed it (a) was stable to heating at 56°C for 1 hr and freezing at −20°C for 1 month; (b) had a molecular weight greater than 30,000; (c) could be induced in sera from athymic nude mice; and (d) was present to a lower degree in sera from aging mice.

Original languageEnglish (US)
Pages (from-to)504-508
Number of pages5
JournalProceedings of the Society for Experimental Biology and Medicine
Volume179
Issue number4
DOIs
StatePublished - Jan 1 1985

Fingerprint

Poly I
Poly C
Poly U
Polynucleotides
Mixed Lymphocyte Culture Test
Poly A
Lymphocytes
Freezing
Aging of materials
Molecular weight
Heating
Serum
Nude Mice
Poly A-U
Poly I-C
Molecular Weight
Hemorrhage

Cite this

Suppression of the Mixed Leukocyte Reaction by Serum from Polynucleotide-Injected Mice. / Odean, Marilyn J; Johnson, Arthur G; Grossberg, Sidney E.

In: Proceedings of the Society for Experimental Biology and Medicine, Vol. 179, No. 4, 01.01.1985, p. 504-508.

Research output: Contribution to journalArticle

@article{c7d2972f514c466db43bd6d9a250e2ba,
title = "Suppression of the Mixed Leukocyte Reaction by Serum from Polynucleotide-Injected Mice",
abstract = "Sera from mice which have been injected iv with either poly(A) · poly(U) or poly(I) · poly(C) 1 1/2 hr prior to bleeding were found to suppress the mixed lymphocyte reaction. This effect was reduced considerably by 18 hr. Characterization of the suppressive sera revealed it (a) was stable to heating at 56°C for 1 hr and freezing at −20°C for 1 month; (b) had a molecular weight greater than 30,000; (c) could be induced in sera from athymic nude mice; and (d) was present to a lower degree in sera from aging mice.",
author = "Odean, {Marilyn J} and Johnson, {Arthur G} and Grossberg, {Sidney E.}",
year = "1985",
month = "1",
day = "1",
doi = "10.3181/00379727-179-42130",
language = "English (US)",
volume = "179",
pages = "504--508",
journal = "Experimental Biology and Medicine",
issn = "1535-3702",
publisher = "Sage Publications",
number = "4",

}

TY - JOUR

T1 - Suppression of the Mixed Leukocyte Reaction by Serum from Polynucleotide-Injected Mice

AU - Odean, Marilyn J

AU - Johnson, Arthur G

AU - Grossberg, Sidney E.

PY - 1985/1/1

Y1 - 1985/1/1

N2 - Sera from mice which have been injected iv with either poly(A) · poly(U) or poly(I) · poly(C) 1 1/2 hr prior to bleeding were found to suppress the mixed lymphocyte reaction. This effect was reduced considerably by 18 hr. Characterization of the suppressive sera revealed it (a) was stable to heating at 56°C for 1 hr and freezing at −20°C for 1 month; (b) had a molecular weight greater than 30,000; (c) could be induced in sera from athymic nude mice; and (d) was present to a lower degree in sera from aging mice.

AB - Sera from mice which have been injected iv with either poly(A) · poly(U) or poly(I) · poly(C) 1 1/2 hr prior to bleeding were found to suppress the mixed lymphocyte reaction. This effect was reduced considerably by 18 hr. Characterization of the suppressive sera revealed it (a) was stable to heating at 56°C for 1 hr and freezing at −20°C for 1 month; (b) had a molecular weight greater than 30,000; (c) could be induced in sera from athymic nude mice; and (d) was present to a lower degree in sera from aging mice.

UR - http://www.scopus.com/inward/record.url?scp=0021837056&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021837056&partnerID=8YFLogxK

U2 - 10.3181/00379727-179-42130

DO - 10.3181/00379727-179-42130

M3 - Article

VL - 179

SP - 504

EP - 508

JO - Experimental Biology and Medicine

JF - Experimental Biology and Medicine

SN - 1535-3702

IS - 4

ER -