Suppression of malaria infection by oxidant-sensitive host erythrocytes

John W. Eaton, James R. Eckman, Elaine Berger, Harry S Jacob

Research output: Contribution to journalArticlepeer-review

62 Scopus citations

Abstract

DEFICIENCY of the red cell enzyme, glucose-6-phosphate dehydrogenase (G-6-PD), predisposes erythrocytes to oxidant-induced haemolysis and is thought to protect humans against severe malaria infection. We have already shown that the malaria parasite exerts an oxidant stress on infected red cells and suggested that premature lysis of malaria infected erythrocytes might occur in G-6-PD deficient humans1, thus limiting the severity of infection by enforcing the release of immature parasites incapable of propagating the infection2.

Original languageEnglish (US)
Pages (from-to)758-760
Number of pages3
JournalNature
Volume264
Issue number5588
DOIs
StatePublished - Dec 1 1976

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