Suppression of long chain acyl-CoA synthetase 3 decreases hepatic de Novo fatty acid synthesis through decreased transcriptional activity

Keyphrases

• Transcriptional Activity 100%
• Long-chain acyl-CoA Synthetase 100%
• Fatty Acid Synthesis 100%
• ACSL3 100%
• Fatty Acid Transport Protein 80%
• Small Interfering RNA (siRNA) 60%
• Fatty Acids 60%
• Gene Activity 40%
• Transcription Factor 40%
• Acyl-CoA Synthetase 40%
• Acyl-CoA 40%
• Protein Isoforms 40%
• Reporter Gene 40%
• Fatty Acid Metabolism 20%
• Control Cell 20%
• Hepatic Energy Metabolism 20%
• ChREBP 20%
• Hepatic Gene Expression 20%
• Tissue Distribution 20%
• Metabolic Pathway 20%
• Acetate 20%
• Knockdown 20%
• Transcriptional Control 20%
• Labeling Experiment 20%
• Distribution Pattern 20%
• Lipid Metabolites 20%
• Primary Hepatocytes 20%
• Substrate Preference 20%
• Liver-specific 20%
• Liver X Receptor 20%
• Metabolic Labeling 20%
• Intracellular Location 20%
• Hepatic Lipogenesis 20%
• Peroxisome Proliferators 20%
• Rat Primary Hepatocytes 20%
• SiRNA Knockdown 20%
• Sterol Regulatory Element-binding protein-1c (SREBP-1c) 20%
• Lipid Extract 20%
• Location Preference 20%
• Lipogenic Transcription Factor 20%
• MRNA Analysis 20%
• High-sucrose Diet 20%
• Activation Receptor 20%

Biochemistry, Genetics and Molecular Biology

• Isoform 100%
• Acyl-CoA 100%
• Fatty Acid Synthesis 100%
• Translocator Protein 80%
• Transcription Factors 60%
• Lipid 40%
• Gene Activity 40%
• Reporter Gene 40%
• Metabolic Pathway 20%
• Metabolite 20%
• Sucrose 20%
• Fatty Acid Metabolism 20%
• Lipogenesis 20%
• Ob/Ob Mouse 20%
• RNA Knockdown 20%
• Carbohydrate-Responsive Element-Binding Protein 20%
• Gene Expression 20%
• Energy Metabolism 20%
• Extract 20%
• Tissue Distribution 20%
• Sterol Regulatory Element Binding Protein 1c 20%
• Liver Cell Culture 20%
• Peroxisome 20%
• Liver X Receptor 20%
• Messenger RNA 20%
• RNAI 20%