Suppression of fixed-ratio operant behavior by β-endorphin

L. Lichtblau, L. H. Fossom, S. B. Sparber

Research output: Contribution to journalArticle

Abstract

Long-Evans hooded rats maintained on a fixed-ratio (FR15) schedule of food reinforcement were given 0.3, 1.5 or 2.9 nmole (1, 5 or 10 μg) of synthetic camel β-endorphin. This produced a dose-related suppression of FR15 responding during the 30 min behavioral session with an ED50 of 0.7 nmole. On a molar basis, β-endorphin is 21 times more potent than morphine in suppressing fixed-ratio responding.

Original languageEnglish (US)
Pages (from-to)No. 355
JournalPharmacologist
Volume19
Issue number2
StatePublished - Jan 1 1977

Fingerprint Dive into the research topics of 'Suppression of fixed-ratio operant behavior by β-endorphin'. Together they form a unique fingerprint.

  • Cite this

    Lichtblau, L., Fossom, L. H., & Sparber, S. B. (1977). Suppression of fixed-ratio operant behavior by β-endorphin. Pharmacologist, 19(2), No. 355.