The effects of nor-binaltorphimine (nor-BNI) and β-funaltrexamine (β-FNA) were studied on the diuretic activities in rats of several kappa opioid agonists including ethylketazocine, tifluadom, bremazocine and U50,488H. Nor-BNI suppressed the diuretic activity of all kappa agonists, whereas β-FNA failed to alter the diuresis. On the other hand, β-FNA treatment completely blocked the morphine-induced antidiuresis, whereas nor-BNI had no effect. The present data add further evidence that nor-BNI is a highly selective antagonist of kappa opioid agonists.
|Original language||English (US)|
|Number of pages||4|
|Journal||Journal of Pharmacology and Experimental Therapeutics|
|State||Published - Dec 1 1988|