Suppression by nor-binaltorphimine of kappa opioid-mediated diuresis in rats

A. E. Takemori, M. M. Schwartz, P. S. Portoghese

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The effects of nor-binaltorphimine (nor-BNI) and β-funaltrexamine (β-FNA) were studied on the diuretic activities in rats of several kappa opioid agonists including ethylketazocine, tifluadom, bremazocine and U50,488H. Nor-BNI suppressed the diuretic activity of all kappa agonists, whereas β-FNA failed to alter the diuresis. On the other hand, β-FNA treatment completely blocked the morphine-induced antidiuresis, whereas nor-BNI had no effect. The present data add further evidence that nor-BNI is a highly selective antagonist of kappa opioid agonists.

Original languageEnglish (US)
Pages (from-to)971-974
Number of pages4
JournalJournal of Pharmacology and Experimental Therapeutics
Issue number3
StatePublished - 1988


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