Superparamagnetic nanoparticle-based viscosity test

Kai Wu, Jinming Liu, Yi Wang, Clark Ye, Yinglong Feng, Jian Ping Wang

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Hyperviscosity syndrome is triggered by high blood viscosity in the human body. This syndrome can result in retinopathy, vertigo, coma, and other unanticipated complications. Serum viscosity is one of the important factors affecting whole blood viscosity, which is regarded as an indicator of general health. In this letter, we propose and demonstrate a Brownian relaxation-based mixing frequency method to test human serum viscosity. This method uses excitatory and detection coils and Brownian relaxation-dominated superparamagnetic nanoparticles, which are sensitive to variables of the liquid environment such as viscosity and temperature. We collect the harmonic signals produced by magnetic nanoparticles and estimate the viscosity of unknown solutions by comparison to the calibration curves. An in vitro human serum viscosity test is performed in less than 1.5 min.

Original languageEnglish (US)
Article number053701
JournalApplied Physics Letters
Volume107
Issue number5
DOIs
StatePublished - Aug 3 2015

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