Superoxide anion production by the autoxidation of cytochrome P450cam

S. G. Sligar, J. D. Lipscomb, P. G. Debrunner, I. C. Gunsalus

Research output: Contribution to journalArticlepeer-review

100 Scopus citations

Abstract

Chemiluminescence occurs on autoxidation of oxygenated ferrous cytochrome P450cam and is abolished by reagents that scavenge free radicals, by superoxide dismutase and singlet oxygen quenchers. We attribute the chemiluminescence to the decay of an excited singlet oxygen which arises from a superoxide anion radical precursor.

Original languageEnglish (US)
Pages (from-to)290-296
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume61
Issue number1
DOIs
StatePublished - Nov 6 1974

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