Superactivated platelets: Thrombus regulators, thrombin generators, and potential clinical targets

Marshall Mazepa, Maureane Hoffman, Dougald Monroe

Research output: Contribution to journalReview articlepeer-review

46 Scopus citations

Abstract

Platelets contribute to hemostasis by forming the platelet plug and then contributing to coagulation by providing a catalytic surface where thrombin generation occurs efficiently. This catalytic activity, known as the platelet procoagulant response, is being recognized as a nuanced response. This review examines platelets' response to strong stimuli, which results in the formation of a platelet subpopulation (superactivated platelets) with several unique properties, including enhanced procoagulant activity. These platelets contribute uniquely to thrombus architecture and seem to have thrombus regulatory activity. Superactivated platelets' role in diseases of thrombosis and hemostasis, as either potentiating or mitigating factors, is not currently known, but may be an important pharmacological target.

Original languageEnglish (US)
Pages (from-to)1747-1752
Number of pages6
JournalArteriosclerosis, thrombosis, and vascular biology
Volume33
Issue number8
DOIs
StatePublished - Aug 2013

Bibliographical note

Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.

Keywords

  • Hemostasis
  • Phosphatidylserine
  • Platelet
  • Procoagulant
  • activation

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